Advancements in Nucleic Acid Based Therapeutics against Respiratory Viral Infections.

ABSTRACT: Several viruses cause pulmonary infections due to their shared tropism with cells of the respiratory tract. These respiratory problems due to viral infection become a public health concern due to rapid transmission through air/aerosols or via direct-indirect contact with infected persons. In addition, the cross-species transmission causes alterations to viral genetic makeup thereby increasing the risk of emergence of pathogens with new and more potent infectivity. With the introduction of effective nucleic acid-based technologies, post translational gene silencing (PTGS) is being increasingly used to silence viral gene targets and has shown promising approach towards management of many viral infections. Since several host factors are also utilized by these viruses during various stages of

SUBMITTER: Asha K 

PROVIDER: S-EPMC6351902 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature