Prospective genomic surveillance of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) associated with bloodstream infection, England, 1 October 2012 to 30 September 2013.

ABSTRACT: BackgroundMandatory reporting of methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI) has occurred in England for over 15years. Epidemiological information is recorded, but routine collection of isolates for characterisation has not been routinely undertaken. Ongoing developments in whole-genome sequencing (WGS) have demonstrated its value in outbreak investigations and for determining the spread of antimicrobial resistance and bacterial population structure. Benefits of adding genomics to routine epidemiological MRSA surveillance are unknown.AimTo determine feasibility and potential utility of adding genomics to epidemiological surveillance of MRSA.MethodsWe conducted an epidemiological and genomic survey of MRSA BSI in England over a 1-year period (1 Oct

SUBMITTER: Toleman MS 

PROVIDER: S-EPMC6351993 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature