The Impact of Cholecystectomy on the Gut Microbiota: A Case-Control Study.

ABSTRACT: Cholecystectomy alters the bile flow into the intestine and the enterohepatic circulation of the bile acids; this may affect the gut microbiota. We assessed the gut microbiota composition of patients who had undergone cholecystectomy and compared with those who had not. From a cohort of 1463 adult participants who underwent comprehensive health screening examinations, 27 subjects who had undergone cholecystectomy (cholecystectomy group) and 81 age- and sex-matched subjects who had not (control group) were selected. Clinical parameters were collected and compared. Microbial composition was determined by 16S rRNA gene sequencing of DNA extracted from fecal samples. We evaluated differences in the overall microbial composition and in the abundance of taxa. The two groups were comparable with

SUBMITTER: Yoon WJ 

PROVIDER: S-EPMC6352247 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature