Segregating sustained attention from response inhibition in ADHD: An fMRI study.

ABSTRACT:

Background

The functional significance of the impairment shown by patients with ADHD on response inhibition tasks is unclear. Dysfunctional behavioral and BOLD responses to rare no-go cues might reflect disruption of response inhibition (mediating withholding the response) or selective attention (identifying the rare cue). However, a factorial go/no-go design (involving high and low frequency go and no-go stimuli) can disentangle these possibilities.

Methods

Eighty youths [22 female, mean age = 13.70 (SD = 2.21), mean IQ = 104.65 (SD = 13.00); 49 with diagnosed ADHD] completed the factorial go/no-go task while undergoing fMRI.

Results

There was a significant response type-by-ADHD symptom severity interaction within the left anterior insula cortex; increasing ADHD symp

SUBMITTER: Hwang S 

PROVIDER: S-EPMC6352299 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature