Rapid Bacterial Species Delineation Based on Parameters Derived From Genome Numerical Representations.

ABSTRACT: Species delineation based on bacterial genomes is an essential part of the research of prokaryotes. In silico genome-to-genome comparison methods are computationally demanding, but much less tedious and error prone than the wet-lab methods. In this paper, we present a novel method for the delineation of bacterial genomes based on genomic signal processing. The proposed method uses numerical representations of whole bacterial genomes, phase signal and cumulated phase signal, from which four parameters are derived for each genome. The parameters characterize a genome and their calculation is independent of the other genomes comprising a delineation dataset. The delineation itself is processed as a calculation of the parameters' average similarity. The method was statistically verified on 182

SUBMITTER: Maderankova D 

PROVIDER: S-EPMC6352304 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature