Prognostic role of PD-L1 for HCC patients after potentially curative resection: a meta-analysis.

ABSTRACT:

Background

A series of studies has investigated the prognostic role and clinical significance of programmed death ligand 1 (PD-L1) in hepatocellular carcinoma (HCC). However, the results were inconsistent. We aimed to clarify the prognostic role of PD-L1 and relationship between PD-L1 expression and several important clinicopathological features.

Methods

PubMed, EMBASE and the Science Citation Index Expanded were systematically searched. All cohort or case-control studies comparing the prognosis and clinical features between the high PD-L1 and low PD-L1 groups were included. Publication bias was evaluated using funnel plots and Begg's test. Subgroup analysis, sensitivity analysis and meta-regression analysis were performed.

Results

Seventeen studies including 2979 pat

SUBMITTER: Liu GM 

PROVIDER: S-EPMC6352338 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature