The active role of the transcription factor Sp1 in NFATc2-mediated gene regulation in pancreatic cancer.

ABSTRACT:

Background

Adenocarcinoma of the pancreas is one of the most aggressive tumor diseases affecting the human body. The oncogenic potential of pancreatic cancer is mainly characterized by extremely rapid growth triggered by the activation of oncogenic signaling cascades, which suggests a change in the regulation of important transcription factors. Amongst others, NFAT transcription factors are assumed to play a central role in the carcinogenesis of pancreatic cancer. Recent research has shown the importance of the transcription factor Sp1 in the transcriptional activity of NFATc2 in pancreatic cancer. However, the role of the interaction between these two binding partners remains unclear. The current study investigated the role of Sp1 proteins in the expression of NFATc2 target genes

SUBMITTER: Malsy M 

PROVIDER: S-EPMC6352339 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature