How to prevent viremia rebound? Evidence from a PRRSv data-supported model of immune response.

ABSTRACT:

Background

Understanding what determines the between-host variability in infection dynamics is a key issue to better control the infection spread. In particular, pathogen clearance is desirable over rebounds for the health of the infected individual and its contact group. In this context, the Porcine Respiratory and Reproductive Syndrome virus (PRRSv) is of particular interest. Numerous studies have shown that pigs similarly infected with this highly ubiquitous virus elicit diverse response profiles. Whilst some manage to clear the virus within a few weeks, others experience prolonged infection with a rebound. Despite much speculation, the underlying mechanisms responsible for this undesirable rebound phenomenon remain unclear.

Results

We aimed at identifying immune mechanis

SUBMITTER: Go N 

PROVIDER: S-EPMC6352383 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature