Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study.

ABSTRACT:

Objectives

We explored the effects of B-cell directed therapy in subjects at risk of developing autoantibodypositive rheumatoid arthritis (RA), who never experienced inflammatory arthritis before, and explored biomarkers predictive of arthritis development.

Methods

Individuals positive for both anti-citrullinated peptide antibodies and rheumatoid factor but without arthritis were included in a randomised, double-blind, placebo-controlled study to receive a single infusion of 1000 mg rituximab or placebo.

Results

Eighty-one individuals received treatment and were followed up for a mean of 29.0 (0-54) months, during which 30/81 (37%) individuals developed arthritis. The observed risk of developing arthritis in the placebo-treated group was 40%, which was decreased by 55

SUBMITTER: Gerlag DM 

PROVIDER: S-EPMC6352407 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature