Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis.

ABSTRACT:

Background

In order to gain insight into the early effects drawn by JAK inhibitors on intra-joint JAK/STAT-dependent signaling, we sought synovial activation of STATs and their end-products, along with their modification with tofacitinib (TOFA), at flare-up in antigen induced arthritis (AIA). New Zealand rabbits were randomly assigned to four groups -healthy controls, AIA, TOFA-treated AIA, or TOFA-treated controls-. AIA was induced with 4 weekly intra-articular ovalbumin injections in sensitized animals. TOFA (10 mg·kg^- 1·day^- 1) was administered for the last 2 weeks. Animals were euthanized 24 h after the last injection.

Results

AIA animals showed high-grade synovitis, which was partially improved by TOFA. No effects of the treatment were found on ser

SUBMITTER: Perez-Baos S 

PROVIDER: S-EPMC6352431 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature