A mathematical model of synaptotagmin 7 revealing functional importance of short-term synaptic plasticity.

ABSTRACT: Synaptotagmin 7 (Syt7), a presynaptic calcium sensor, has a significant role in the facilitation in short-term synaptic plasticity: Syt7 knock out mice show a significant reduction in the facilitation. The functional importance of short-term synaptic plasticity such as facilitation is not well understood. In this study, we attempt to investigate the potential functional relationship between the short-term synaptic plasticity and postsynaptic response by developing a mathematical model that captures the responses of both wild-type and Syt7 knock-out mice. We then studied the model behaviours of wild-type and Syt7 knock-out mice in response to multiple input action potentials. These behaviors could establish functional importance of short-term plasticity in regulating the postsynaptic respon

SUBMITTER: He Y 

PROVIDER: S-EPMC6352580 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature