Hepatocyte Aggregate Formation on Chitin-Based Anisotropic Microstructures of Butterfly Wings.

ABSTRACT: Scaffold nanotopography plays the most significant role in the mimicry of the in vivo microenvironment of the hepatocytes. Several attempts have been made to develop methods and substrates suited to growing hepatocytes into aggregates. Functional biomaterials, particularly biodegradable polymers, have been used in several studies aimed to develop improved scaffolds with ordered geometry and nanofibrous architecture for tissue engineering. However, there are still some limitation in their fabrication: it is not cost-efficient, is time-consuming, and exhibits some technological complications. The synthetic scaffolds are usually non-biodegradable and can be non-biocompatible compared to the naturally derived biomaterials. Here, we utilized a simple, cost-effective, and green method with two-s

SUBMITTER: Elbaz A 

PROVIDER: S-EPMC6352657 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature