Mechanically Reinforced Catechol-Containing Hydrogels with Improved Tissue Gluing Performance.

ABSTRACT: In situ forming hydrogels with catechol groups as tissue reactive functionalities are interesting bioinspired materials for tissue adhesion. Poly(ethylene glycol) (PEG)⁻catechol tissue glues have been intensively investigated for this purpose. Different cross-linking mechanisms (oxidative or metal complexation) and cross-linking conditions (pH, oxidant concentration, etc.) have been studied in order to optimize the curing kinetics and final cross-linking degree of the system. However, reported systems still show limited mechanical stability, as expected from a PEG network, and this fact limits their potential application to load bearing tissues. Here, we describe mechanically reinforced PEG⁻catechol adhesives showing excellent and tunable cohesive properties and adhesive performance to tis

SUBMITTER: Feng J 

PROVIDER: S-EPMC6352675 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature