HIV-related excess mortality and age-related comorbidities in patients with HIV aged ≥60: a relative survival analysis in the French Dat'AIDS cohort.

ABSTRACT:

Objective

The objective was to evaluate the association between age-related comorbidities (ARCs) and 5-year HIV-related excess mortality in people living with HIV aged ≥60 years.

Design

Cohort study using relative survival analysis (Estève's model).

Setting

The French multicentre prospective Dat'AIDS cohort that involves 12 French hospitals.

Participants

Inclusion of 1415 HIV-1 infected patients actively followed aged ≥60 years on January 2008, with a 5-year follow-up period in the late combination antiretroviral therapy era.

Results

Among 1415 patients included, 154 died. By multivariable analysis, factors predictive of 5-year HIV-related excess mortality were non-AIDS-related cancer (adjusted excess HR (aEHR)=2.94; 95% CI 1.32 to 6.57), cardiovascular

SUBMITTER: Hentzien M 

PROVIDER: S-EPMC6352790 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature