The functional consequences of sodium channel Na_V 1.8 in human left ventricular hypertrophy.

ABSTRACT:

Aims

In hypertrophy and heart failure, the proarrhythmic persistent Na⁺ current (I_NaL ) is enhanced. We aimed to investigate the electrophysiological role of neuronal sodium channel Na_V 1.8 in human hypertrophied myocardium.

Methods and results

Myocardial tissue of 24 patients suffering from symptomatic severe aortic stenosis and concomitant significant afterload-induced hypertrophy with preserved ejection fraction was used and compared with 12 healthy controls. We performed quantitative real-time PCR and western blot and detected a significant up-regulation of Na_V 1.8 mRNA (2.34-fold) and protein expression (1.96-fold) in human hypertrophied myocardium compared with healthy hearts. Interestingly, Na_V 1.5 protein express

SUBMITTER: Ahmad S 

PROVIDER: S-EPMC6352890 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature