The dynamic side of the Warburg effect: glycolytic intermediate storage as buffer for fluctuating glucose and O ₂ supply in tumor cells.

ABSTRACT: Background: Tumor cells often show altered metabolism which supports uncontrolled proliferation. A classic example is the Warburg effect: high glucose uptake and lactate production despite sufficient oxygen supply. Remarkably, tumor cells can transiently take up glucose even an order of magnitude faster when glucose is reintroduced after depletion. Regulation and significance of this high glucose uptake are investigated here. Methods: A new computational model was developed which reproduces two types of experimental data on Ehrlich ascites tumor cells: measurements by Otto Warburg of the average aerobic glycolytic rate during one hour (Warburg effect), and fast metabolic responses measured by others during the first minutes after reintroducing glucose. The model is subsequent

SUBMITTER: van Beek JHGM 

PROVIDER: S-EPMC6352925 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature