Impaired Glucose Homeostasis in First-Episode Schizophrenia: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Schizophrenia is associated with an increased risk of type 2 diabetes. However, it is not clear whether schizophrenia confers an inherent risk for glucose dysregulation in the absence of the effects of chronic illness and long-term treatment.

Objective

To conduct a meta-analysis examining whether individuals with first-episode schizophrenia already exhibit alterations in glucose homeostasis compared with controls.

Data sources

The EMBASE, MEDLINE, and PsycINFO databases were systematically searched for studies examining measures of glucose homeostasis in antipsychotic-naive individuals with first-episode schizophrenia compared with individuals serving as controls.

Study selection

Case-control studies reporting on fasting plasma glucose levels, plasma

SUBMITTER: Pillinger T 

PROVIDER: S-EPMC6352957 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature