Evidence for a subcircuit in medial entorhinal cortex representing elapsed time during immobility.

ABSTRACT: The medial entorhinal cortex (MEC) is known to contain spatial encoding neurons that likely contribute to encoding spatial aspects of episodic memories. However, little is known about the role MEC plays in encoding temporal aspects of episodic memories, particularly during immobility. Here using a virtual 'Door Stop' task for mice, we show that MEC contains a representation of elapsed time during immobility, with individual time-encoding neurons activated at a specific moment during the immobile interval. This representation consisted of a sequential activation of time-encoding neurons and displayed variations in progression speed that correlated with variations in mouse timing behavior. Time- and space-encoding neurons were preferentially active during immobile and locomotion periods, res

SUBMITTER: Heys JG 

PROVIDER: S-EPMC6352992 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature