Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome.

ABSTRACT:

Rationale

MMPs (Matrix metalloproteinases) and their endogenous tissue inhibitors may contribute to lung injury through extracellular matrix degradation and modulation of inflammation and fibrosis.

Objectives

To test for an association between MMP pathway proteins and inflammation, endothelial dysfunction, and clinical outcomes.

Methods

We measured MMPs in plasma collected on acute respiratory distress syndrome (ARDS) Day 1 from 235 children at five hospitals between 2008 and 2017. We used latent class analysis to identify patients with distinct MMP profiles and then associated those profiles with markers of inflammation (IL-1RA, -6, -8, -10, and -18; macrophage inflammatory protein-1α and -1β; tumor necrosis factor-α and -R2), endothelial injury (angiopoietin-2, von

SUBMITTER: Zinter MS 

PROVIDER: S-EPMC6353006 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature