Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027.

ABSTRACT: Toxin synthesis and endospore formation are two of the most critical factors that determine the outcome of infection by Clostridioides difficile. The two major toxins, TcdA and TcdB, are the principal factors causing damage to the host. Spores are the infectious form of C. difficile, permit survival of the bacterium during antibiotic treatment and are the predominant cell form that leads to recurrent infection. Toxin production and sporulation have their own specific mechanisms of regulation, but they share negative regulation by the global regulatory protein CodY. Determining the extent of such regulation and its detailed mechanism is important for understanding the linkage between two apparently independent biological phenomena and raises the possibility of creating new ways of limiting

SUBMITTER: Daou N 

PROVIDER: S-EPMC6353076 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature