The association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse.

ABSTRACT:

Background

Alcohol dependence displays a wide variety of clinical phenotypes. Various typology classifications of alcoholism include age of onset of alcohol abuse as one of the major phenotypic features. Serotonergic changes have been associated with alcoholism, while serotonin receptors type 1B (5-HT1B) play an important role in regulating serotonergic neurotransmission. The rs13212041 polymorphism modulates the expression of HTR1B gene coding for 5-HT1B receptor. This study examined the association of platelet serotonin (5-HT) and HTR1B gene with the onset of alcohol abuse in alcohol-dependent subjects.

Materials and methods

Determination of platelet 5-HT concentration and genotyping of rs13212041 HTR1B gene polymorphism were performed in 613 alcohol-d

SUBMITTER: Svob Strac D 

PROVIDER: S-EPMC6353223 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature