Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study.

ABSTRACT:

Importance

DNA methylation may play an important role in schizophrenia (SZ), either directly as a mechanism of pathogenesis or as a biomarker of risk.

Objective

To scan genome-wide DNA methylation data to identify differentially methylated CpGs between SZ cases and controls.

Design, setting, and participants

Epigenome-wide association study begun in 2008 using DNA methylation levels of 456 513 CpG loci measured on the Infinium HumanMethylation450 array (Illumina) in a consortium of case-control studies for initial discovery and in an independent replication set. Primary analyses used general linear regression, adjusting for age, sex, race/ethnicity, smoking, batch, and cell type heterogeneity. The discovery set contained 689 SZ cases and 645 controls (n = 1334), from

SUBMITTER: Montano C 

PROVIDER: S-EPMC6353566 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature