A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks.

ABSTRACT: Aging is regarded as a major risk factor for neurodegenerative diseases. Thus, a better understanding of the similarities between the aging process and neurodegenerative diseases at the cellular and molecular level may reveal better understanding of this detrimental relationship. In the present study, we mined publicly available gene expression datasets from healthy individuals and patients affected by neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, and Huntington's disease) across a broad age spectrum and compared those with mouse aging and mouse cell-type specific gene expression profiles. We performed weighted gene co-expression network analysis (WGCNA) and found a gene network strongly related with both aging and neurodegenerative diseases. This network was signif

SUBMITTER: Mukherjee S 

PROVIDER: S-EPMC6353788 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature