Establishment of a transgenic mouse to model ETV7 expressing human tumors.

ABSTRACT: The ETS transcription factor ETV7 has been characterized as a hematopoietic oncoprotein, which requires cooperating mutations for its leukemogenic activity. Although the ETV7 gene is highly conserved among vertebrates, part of the rodents, including Mus musculus, deleted the Etv7 gene locus. Many human hematopoietic malignancies upregulate ETV7 expression but contrary to ETV7's role in oncogenesis, its physiological role in normal tissues is unknown. To determine the physiological function of ETV7 in vivo and determine its role in tumorigenesis in a mouse model, we have generated an ETV7 transgenic mouse that carries a single copy of human BAC DNA containing the ETV7 gene locus and its regulatory sequences. ETV7 heterozygous (ETV7Tg^+/WT) mice were fertile, normal in size and bor

SUBMITTER: Numata M 

PROVIDER: S-EPMC6353817 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature