Interventions to improve oral vaccine performance: a systematic review and meta-analysis.

ABSTRACT:

Background

Oral vaccines underperform in low-income and middle-income countries compared with in high-income countries. Whether interventions can improve oral vaccine performance is uncertain.

Methods

We did a systematic review and meta-analysis of interventions designed to increase oral vaccine efficacy or immunogenicity. We searched Ovid-MEDLINE and Embase for trials published until Oct 23, 2017. Inclusion criteria for meta-analysis were two or more studies per intervention category and available seroconversion data. We did random-effects meta-analyses to produce summary relative risk (RR) estimates. This study is registered with PROSPERO (CRD42017060608).

Findings

Of 2843 studies identified, 87 were eligible for qualitative synthesis and 66 for meta-analysis. 22 di

SUBMITTER: Church JA 

PROVIDER: S-EPMC6353819 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature