Identification of Pre-frailty Sub-Phenotypes in Elderly Using Metabolomics.

ABSTRACT: Aging is a dynamic process depending on intrinsic and extrinsic factors and its evolution is a continuum of transitions, involving multifaceted processes at multiple levels. It is recognized that frailty and sarcopenia are shared by the major age-related diseases thus contributing to elderly morbidity and mortality. Pre-frailty is still not well understood but it has been associated with global imbalance in several physiological systems, including inflammation, and in nutrition. Due to the complex phenotypes and underlying pathophysiology, the need for robust and multidimensional biomarkers is essential to move toward more personalized care. The objective of the present study was to better characterize the complexity of pre-frailty phenotype using untargeted metabolomics, in order to ident

SUBMITTER: Pujos-Guillot E 

PROVIDER: S-EPMC6353829 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature