Analysis of the relationship between the gut microbiome and dementia: a cross-sectional study conducted in Japan.

ABSTRACT: Dysregulation of the gut microbiome is associated with several life-threatening conditions and thus might represent a useful target for the prevention of dementia. However, the relationship between the gut microbial population and dementia has not yet been fully clarified. We recruited outpatients visiting our memory clinic to participate in this study. Information on patient demographics, risk factors, and activities of daily living was collected, and cognitive function was assessed using neuropsychological tests and brain magnetic resonance imaging scans. Faecal samples were obtained, and the gut microbiome was assessed by terminal restriction fragment length polymorphism (T-RFLP) analysis, one of the most well-established and reliable 16S ribosomal RNA-based methods for classifying gut

SUBMITTER: Saji N 

PROVIDER: S-EPMC6353871 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature