Circulating inflammation signature predicts overall survival and relapse-free survival in metastatic colorectal cancer.

ABSTRACT:

Background

Metastatic colorectal cancer (mCRC) is a highly heterogeneous disease from a clinical, molecular, and immunological perspective. Current predictive models rely primarily in tissue based genetic analysis, which not always correlate with inflammatory response. Here we evaluated the role of a circulating inflammatory signature as a prognostic marker in mCRC.

Methods

Two hundred eleven newly diagnosed patients with mCRC were enrolled in the study. One hundred twenty-one patients had unresectable metastases, whereas ninety patients had potentially resectable liver metastases at presentation. Analysis of miR-21, IL-6, and IL-8 in the plasma of peripheral blood was performed at baseline. Patients with high circulating levels of ≥2 of the three inflammation markers (miR-2

SUBMITTER: Varkaris A 

PROVIDER: S-EPMC6353894 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature