HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Metabolic changes in tumour cells are used in clinical imaging and may provide potential therapeutic targets. Human papillomavirus (HPV) status is important in classifying head and neck cancers (HNSCC), identifying a distinct clinical phenotype; metabolic differences between these HNSCC subtypes remain poorly understood.

Methods

We used RNA sequencing to classify the metabolic expression profiles of HPV^+ve and HPV^-ve HNSCC, performed a meta-analysis on FDG-PET imaging characteristics and correlated results with in vitro extracellular flux analysis of HPV^-ve and HPV^+ve HNSCC cell lines. The monocarboxylic acid transporter-1 (MCT1) was identified as a potential metabolic target and tested in functional assays.

Results</

SUBMITTER: Fleming JC 

PROVIDER: S-EPMC6353968 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature