Dosage Compensation of the X Chromosomes in Bovine Germline, Early Embryos, and Somatic Tissues.

ABSTRACT: Dosage compensation of the mammalian X chromosome (X) was proposed by Susumu Ohno as a mechanism wherein the inactivation of one X in females would lead to doubling the expression of the other. This would resolve the dosage imbalance between eutherian females (XX) versus male (XY) and between a single active X versus autosome pairs (A). Expression ratio of X- and A-linked genes has been relatively well studied in humans and mice, despite controversial results over the existence of upregulation of X-linked genes. Here we report the first comprehensive test of Ohno's hypothesis in bovine preattachment embryos, germline, and somatic tissues. Overall an incomplete dosage compensation (0.5 < X:A < 1) of expressed genes and an excess X dosage compensation (X:A > 1) of ubiquitously expressed "dos

SUBMITTER: Duan JE 

PROVIDER: S-EPMC6354180 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature