Population-based cohort study of the impact on postoperative mortality of anastomotic leakage after anterior resection for rectal cancer.

ABSTRACT: Background:Anastomotic leakage following anterior resection for rectal cancer may result in death. The aim of this study was to yield an updated, population-based estimate of postoperative mortality and evaluate possible interacting factors. Methods:This was a retrospective national cohort study of patients who underwent anterior resection between 2007 and 2016. Data were retrieved from a prospectively developed database. Anastomotic leakage constituted exposure, whereas outcome was defined as death within 90 days of surgery. Logistic regression analyses, using directed acyclic graphs to evaluate possible confounders, were performed, including interaction analyses. Results:Of 6948 patients, 693 (10·0 per cent) experienced anastomotic leakage and 294 (4·2 per cent) underwent reintervention

SUBMITTER: Bostrom P 

PROVIDER: S-EPMC6354192 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature