¹¹C-DPA-713 Versus ¹⁸F-GE-180: A Preclinical Comparison of Translocator Protein 18 kDa PET Tracers to Visualize Acute and Chronic Neuroinflammation in a Mouse Model of Ischemic Stroke.

ABSTRACT: Neuroinflammation plays a key role in neuronal injury after ischemic stroke. PET imaging of translocator protein 18 kDa (TSPO) permits longitudinal, noninvasive visualization of neuroinflammation in both preclinical and clinical settings. Many TSPO tracers have been developed, however, it is unclear which tracer is the most sensitive and accurate for monitoring the in vivo spatiotemporal dynamics of neuroinflammation across applications. Hence, there is a need for head-to-head comparisons of promising TSPO PET tracers across different disease states. Accordingly, the aim of this study was to directly compare 2 promising second-generation TSPO tracers, ¹¹C-DPA-713 and ¹⁸F-GE-180, for the first time at acute and chronic time points after ischemic stroke. Methods:

SUBMITTER: Chaney A 

PROVIDER: S-EPMC6354224 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature