Synthesis and Preclinical Characterization of the PSMA-Targeted Hybrid Tracer PSMA-I&F for Nuclear and Fluorescence Imaging of Prostate Cancer.

ABSTRACT: The prostate-specific membrane antigen (PSMA)-targeted radiotracers ⁶⁸Ga/¹⁷⁷Lu-PSMA-I&T and ^99mTc-PSMA-I&S (for i maging and s urgery) are currently successfully used for clinical PET imaging, radionuclide therapy, and radioguided surgery of metastatic prostate cancer. To additionally exploit the high sensitivity and spatial resolution of fluorescence imaging for improved surgical guidance, a PSMA-I&T-based hybrid tracer, PSMA-I&F (DOTAGA-k(Sulfo-Cy5)-y-nal-k-Sub-KuE), has been developed and evaluated. Methods: The in vitro PSMA-targeting efficiency of PSMA-I&F, the reference PSMA-I&T, and their corresponding ^natGa-/⁶⁸Ga- and ^natLu/¹⁷⁷Lu counterparts was determined in LNCaP cells

SUBMITTER: Schottelius M 

PROVIDER: S-EPMC6354225 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature