Dhcr24 activates the PI3K/Akt/HKII pathway and protects against dilated cardiomyopathy in mice.

ABSTRACT:

Background

24-dehydrocholesterol reductase (Dhcr24) catalyzes the last step of cholesterol biosynthesis, which is required for normal development and anti-apoptotic activities of tissues. We found that Dhcr24 expression decreased in the cTnT^{R 141W} dilated cardiomyopathy (DCM) transgenic mice. Therefore, we tested whether rescued expression of Dhcr24 could prevent the development of DCM and its possible mechanism.

Methods

Heart tissue specific transgenic overexpression mice of Dhcr24 was generated, then was crossed to cTnT^{R 141W} mouse to obtain the double transgenic mouse (DTG). The phenotypes were demonstrated by the survival, cardiac geometry and function analysis, as well as microstructural and ultrastructural observations based

SUBMITTER: Dong W 

PROVIDER: S-EPMC6354314 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature