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Current trends in the treatment of pneumonia due to multidrug-resistant Gram-negative bacteria.


ABSTRACT: Pneumonia is one of the most common infections worldwide. Morbidity, mortality, and healthcare costs increase substantially when pneumonia is caused by multidrug-resistant Gram-negative bacteria (MDR-GNB). The ongoing spread of antimicrobial resistance has made treating MDR-GNB pneumonia increasingly difficult. Fortunately, there have been some recent additions to our antibiotic armamentarium in the US and Europe for MDR-GNB, along with several agents that are in advanced stages of development. In this article, we review the risk factors for and current management of MDR-GNB pneumonia as well as novel agents with activity against these important and challenging pathogens.

SUBMITTER: Watkins RR 

PROVIDER: S-EPMC6354321 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Current trends in the treatment of pneumonia due to multidrug-resistant Gram-negative bacteria.

Watkins Richard R RR   Van Duin David D  

F1000Research 20190130


Pneumonia is one of the most common infections worldwide. Morbidity, mortality, and healthcare costs increase substantially when pneumonia is caused by multidrug-resistant Gram-negative bacteria (MDR-GNB). The ongoing spread of antimicrobial resistance has made treating MDR-GNB pneumonia increasingly difficult. Fortunately, there have been some recent additions to our antibiotic armamentarium in the US and Europe for MDR-GNB, along with several agents that are in advanced stages of development.  ...[more]

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