Incidental screen positive findings in a prospective cohort study in Matlab, Bangladesh: insights into expanded newborn screening for low-resource settings.

ABSTRACT:

Background

Newborn screening programs are essential preventative public health initiatives but are not widely available in low-resource settings. The objective of this study was to describe the frequency and nature of screen positive determinations as made by a Canadian newborn screening program in a cohort of infants born in Matlab, Bangladesh. Dried newborn cord and heel-prick blood spot samples collected as part of a validation study nested within a preterm birth research cohort were collected between January 2017 and July 2018 and analyzed in a Canadian newborn screening laboratory where the laboratory's disease panel and screening thresholds were applied.

Results

A total of 1661 newborn samples (520 heel-prick and 1141 cord blood samples) were available for analysis. Ba

SUBMITTER: Murphy MSQ 

PROVIDER: S-EPMC6354381 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature