Comparison of splenocyte microRNA expression profiles of pigs during acute and chronic toxoplasmosis.

ABSTRACT:

Background

Toxoplasma gondii is an obligate intracellular parasite that infects humans and other warm-blooded animals. Previous quantitative proteomic analyses of infected host cells revealed that the expression of many host proteins is modulated by T. gondii infection. However, at present limited data are available on the differentially expressed miRNAs (DEMs) associated with the pathology and host immune responses induced by acute and chronic infection with T. gondii in pigs in vivo. In this study, high-throughput sequencing was used to investigate expression profiles of spleen miRNAs at 10, 25 and 50 days post-infection (DPI) in pigs infected with Chinese I genotype strain T. gondii isolated from a dead pig.

Results

When compared to the control group, 34, 6 and 86 DEMs we

SUBMITTER: Hou Z 

PROVIDER: S-EPMC6354428 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature