CSF1R antagonism limits local restimulation of antiviral CD8⁺ T cells during viral encephalitis.

ABSTRACT:

Background

Microglia are resident macrophages of the central nervous system (CNS) locally maintained through colony-stimulating factor 1 receptor (CSF1R) signaling. Microglial depletion via CSF1R inactivation improves cognition in mouse models of neuroinflammation, but limits virologic control in the CNS of mouse models of neurotropic infections by unknown mechanisms. We hypothesize that CSF1R plays a critical role in myeloid cell responses that restrict viral replication and locally restimulate recruited antiviral T cells within the CNS.

Methods

The impact of CSF1R signaling during West Nile virus infection was assessed in vivo using a mouse model of neurotropic infection. Pharmacological inactivation of CSF1R was achieved using PLX5622 prior to infection with virulent or a

SUBMITTER: Funk KE 

PROVIDER: S-EPMC6354430 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature