Metabolic adaptation in the human gut microbiota during pregnancy and the first year of life.

ABSTRACT:

Background

The relationship between the gut microbiome and the human host is dynamic and we may expect adjustments in microbiome function if host physiology changes. Metatranscriptomic approaches should be key in unraveling how such adjustments occur.

Methods

We employ metatranscriptomic sequencing analyses to study gene expression in the gut microbiota of infants through their first year of life, and of their mothers days before delivery and one year afterwards.

Findings

In infants, hallmarks of aerobic metabolism disappear from the microbial metatranscriptome as development proceeds, while the expression of functions related to carbohydrate transport and metabolism increases and diversifies, approaching that observed in non-pregnant women. Butyrate synthesis enzymes

SUBMITTER: Gosalbes MJ 

PROVIDER: S-EPMC6354444 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature