Randomized trial of three doses of vitamin D to reduce deficiency in pregnant Mongolian women.

ABSTRACT:

Background

In winter in Mongolia, 80% of adults have 25-hydroxyvitamin D (25(OH)D) concentrations <25 nmol/l (<10 ng/ml) and 99% have <50 nmol/l (<20 ng/ml). The vitamin D dose to avert deficiency during pregnancy in this population is unknown.

Methods

We conducted a randomized, controlled, double-blind trial of daily 600, 2000, or 4000 IU vitamin D₃ for pregnant women in Mongolia (Clinicaltrials.gov #NCT02395081). We examined 25(OH)D concentrations at baseline (12-16 weeks' gestation), 36-40 weeks' gestation and in umbilical cord blood, using enzyme linked fluorescent assay. Sample size was determined to detect 0.4 standard deviation differences in 25(OH)D concentrations with 80% power.

Findings

119 pregnant women were assigned 600 IU, 121 assigned 2000 IU

SUBMITTER: Enkhmaa D 

PROVIDER: S-EPMC6354654 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature