Gastric Helicobacter pylori infection perturbs human oral microbiota.

ABSTRACT:

Background

We investigated the effects of gastric Helicobacter pylori infection on the daytime and overnight human oral microbiota.

Methods

Twenty four volunteers were recruited. Ten tested positive for H. pylori infection by the Carbon-14 Urea Breath Test, and the rest were negative. Two oral swabs were collected: one immediately after waking up in the morning and before brushing teeth, and another in the evening before teeth-brushing. DNA extract acquired from each swab was subjected to Illumina sequencing of 16S rRNA gene amplicons. The microbial abundance and composition were analysed in relation to H. pylori infection status.

Results

Helicobacter pylori-positive individuals had significant changes in the alpha and beta diversiti

SUBMITTER: Chua EG 

PROVIDER: S-EPMC6354663 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature