Molecular profiling of longitudinally observed small colorectal polyps: A cohort study.

ABSTRACT:

Background

Knowledge of the natural history of colorectal adenomas is limited because these lesions are removed upon detection. The few studies in which small adenomas have been left in situ for a limited period of time, have shown that most lesions remain stable or even completely regress. Specific DNA copy number changes ('cancer associated events' or CAEs) are associated with progression of adenomas to cancer. In this study we evaluated whether molecular features of progression correlated with growth of small polyps.

Methods

Small (6-9 mm) colorectal precursor lesions detected on CT-colonography (CTC) were left in situ and re-evaluated with CTC after three years. Based on volumetric change, polyps were classified as either grown, stable or regressed. Surveillance CTC was

SUBMITTER: van Lanschot MCJ 

PROVIDER: S-EPMC6354708 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature