HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction.

ABSTRACT:

Background

Epigenetic histone acetylation is a major event controlling cell functions, such as metabolism, differentiation and repair. Here, we aim to determine whether Valproic acid (VPA), a FDA approved inhibitor of histone deacetylation for bipolar disease, could protect heart against myocardial infarction (MI) injury and elucidate key molecular pathways.

Methods

VPA was administrated to MI rats at different time points, onset and after MI injury. Echocardiography, histology, serum biology assays, and gene expression, inhibition, and over-expression were performed to characterize the systolic function, infarct size, gene and signaling pathways.

Findings

VPA treatment reduced the infarct size by ~50% and preserved the systolic function of heart after acute MI in rat

SUBMITTER: Tian S 

PROVIDER: S-EPMC6354709 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature