FOXP1 negatively regulates tumor infiltrating lymphocyte migration in human breast cancer.

ABSTRACT:

Background

FOXP1, a transcriptional regulator of lymphocyte development, is abnormally expressed in some human tumors. This study investigated FOXP1-mediated regulation of tumor infiltrating lymphocytes (TIL) in untreated primary breast cancer (BC).

Methods

FOXP1 expression was analyzed in tissues from primary untreated breast tumors, BC cell lines and the METABRIC gene expression BC dataset. Cytokine and chemokine expression and lymphocyte migration in response to primary tumor supernatants (SN) was compared between FOXP1^hi and FOXP1^lo primary BC.

Finding

FOXP1 expression was higher in estrogen receptor positive compared to negative BC. FOXP1^hi tumors were significantly associated with lower TIL and fewer tertiary lymphoid structures

SUBMITTER: De Silva P 

PROVIDER: S-EPMC6354712 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature