Diabetes mellitus induced by somatostatin analogue therapy is not permanent in acromegalic patients.

ABSTRACT:

Context

Therapy with somatostatin analogues (SSAs) may have deleterious effects on glucose metabolism in patients with acromegaly, often leading to the development of diabetes mellitus (DM).

Aim

The aim of the study was to evaluate whether DM, developed during therapy with SSAs, may revert after drug withdrawal and cure of acromegaly with pituitary adenomectomy.

Design

Retrospective cohort study, in a tertiary referral centre.

Patients

Eighteen acromegalic patients without DM at the diagnosis of acromegaly treated with SSAs as a primary therapy, and then cured by pituitary adenomectomy.

Methods

Endocrine status and glucose homeostasis were evaluated at diagnosis of acromegaly and at least every 6 months during SSA therapy. At each visit, patients were cl

SUBMITTER: Cappellani D 

PROVIDER: S-EPMC6354758 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature