Hospital admissions for severe infections in people with chronic kidney disease in relation to renal disease severity and diabetes status.

ABSTRACT:

Background

Immunosuppressive agents are being investigated for the treatment of chronic kidney disease (CKD) but may increase risk of infection. This was a retrospective observational study intended to evaluate the risk of hospitalized infection in patients with CKD, by estimated glomerular filtration rate (eGFR) and proteinuria status, aiming to identify the most appropriate disease stage for immunosuppressive intervention.

Methods

Routine UK primary-care and linked secondary-care data were extracted from the Clinical Practice Research Datalink. Patients with a record of CKD were identified and grouped into type 2, type 1 and nondiabetes cohorts. Time-dependent, Cox proportional hazard models were used to determine the likelihood of hospitalized infection.

Results

We

SUBMITTER: Berni E 

PROVIDER: S-EPMC6354815 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature