Duration and onset of action of high dose U-500 regular insulin in severely insulin resistant subjects with type 2 diabetes.

ABSTRACT:

Aim

Although regular human U-500 insulin (U-500) is frequently used for insulin resistant type 2 diabetics, pharmacokinetic and pharmacodynamic studies in these individuals are lacking. We set out to determine the rate of onset, duration of action and total glucose lowering effect of two doses of U-500 insulin in obese insulin resistant subjects with type 2 diabetes.

Materials and methods

Randomized double-blind crossover study was designed to study subjects who were administered either 100 or 200 units SQ of U-500 insulin once and then were provided intravenous glucose as necessary to maintain euglycaemia.

Results

A total of 12 subjects were studied. The time during which intravenous glucose was required to maintain euglycaemia following a 200-unit dose of U-500 insu

SUBMITTER: Shrestha RT 

PROVIDER: S-EPMC6354819 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature