GATA4 molecular screening and assessment of environmental risk factors in a Moroccan cohort with tetralogy of Fallot.

ABSTRACT:

Background

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect (CHD) with an incidence of 1/3600 live births. This disorder was associated with mutations in the transcription factors involved in cardiogenesis, like Nk2 homeobox5 (NKX2-5), GATA binding protein4 (GATA4) and T-BOX1 (TBX1). GATA4 contributes particularly to heart looping and differentiation of the second heart field.

Objectives

The aim of this study was to screen a Moroccan cohort with tetralogy of Fallot for GATA4 mutations, and to assess environmental risk factors that could be involved in the occurrence of this disorder.

Methods

Thirty-one non-syndromic TOF patients, enrolled between 5^th April 2014 and 18^th June 2015, were screened for GATA4 mutations usi

SUBMITTER: El Bouchikhi I 

PROVIDER: S-EPMC6354854 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature