Genetic diversity of hepatitis B co-infection with hepatitis C, D and E viruses among Malaysian chronic hepatitis B patients.

ABSTRACT:

Background

Hepatitis B virus co-infection with other strains of viral hepatitis is associated with increased risk of liver cirrhosis and hepatic decompensation.

Objectives

This is a prevalence study that assessed the genetic diversity of chronic hepatitis B patients and coinfection.

Methods

Chronic hepatitis B patients enrolled in this study were tested for antibodies of other hepatitis viruses using ELISA kits. Patient clinical profiles were collected and partial genes of HBV, HCV, and HEV were amplified, sequenced, and analyzed using phylogenetic analysis. The associations between variables were determined using the chi-squared test.

Results

Of the 82 patients recruited for this study, 53.7% were non-cirrhotic, 22.0% cirrhotic, 20.7% acute flare and 3.7% hepa

SUBMITTER: Hudu SA 

PROVIDER: S-EPMC6354894 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature