T cell-intrinsic prostaglandin E₂-EP2/EP4 signaling is critical in pathogenic T_H17 cell-driven inflammation.

ABSTRACT:

Background

IL-23 is the key cytokine for generation of pathogenic IL-17-producing helper T (T_H17) cells, which contribute critically to autoimmune diseases. However, how IL-23 generates pathogenic T_H17 cells remains to be elucidated.

Objectives

We sought to examine the involvement, molecular mechanisms, and clinical implications of prostaglandin (PG) E₂-EP2/EP4 signaling in induction of IL-23-driven pathogenic T_H17 cells.

Methods

The role of PGE₂ in induction of pathogenic T_H17 cells was investigated in mouse T_H17 cells in culture in vitro and in an IL-23-induced psoriasis mouse model in vivo. Clinical relevance of the findings in mice was examined by using gene expression profiling of IL-23

SUBMITTER: Lee J 

PROVIDER: S-EPMC6354914 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature